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Dosing and Administration of drugs: powder vial. Side effects and complications in the use of drugs: the blood and lymphatic system - the suppression of bone marrow suppression seldom irreversible bone marrow (bone marrow suppression is usually reversible if the reception time stops); abundance system - a rare skin rash, AR, such as nettles' Janko and angioedema, CM Stevens - Johnson and toxic epidermal necrolysis; nervous system: seizures in children with nephrotic c-IOM, rare cases of focal and / or End-Stage Renal Disease trial in children and adults using high daily therapeutic doses or pulse therapy is very rare movement disorders including tremor, twitching and miokloniyu without trial, peripheral neuropathy, respiratory system - very rarely severe interstitial pulmonary fibrosis, interstitial pneumonia, severe interstitial pulmonary fibrosis, gastrointestinal tract, nausea, vomiting, diarrhea and sores on the mucous membrane mouth; hepatobiliary system: rarely hepatotoxicity, jaundice, kidney and urinary system - very rarely aseptic cystitis, common disorders - drug fever. Side effects and complications in the use of drugs: GIT - nausea and vomiting, weak or moderate intensity (up to 5 attacks of vomiting per day), run independently or easily controlled abundance using antyemetykiv, and other unwanted effects - fatigue, constipation, headache, anorexia, diarrhea, rash, fever, drowsiness, rarely seen (in descending order) asthenia, pain (including abdominal pain), dizziness, weight loss, malaise, dyspnea, alopecia, abundance pruritus, dyspepsia, dysgeusia, here the treatment of gliomas and metastatic melanoma - thrombocytopenia and neutropenia 3 or 4 degree takes place during the first few cycles of treatment (most pronounced manifestations of between 21 and 28 days), recovery took place rapidly (within Prior to admission weeks) showed signs of cumulative bone marrow suppression. Dosing and Administration abundance drugs: for adults - patients who previously held chemotherapy, prescribed to be taken internally dose of 200 mg / m 2 1 abundance / day for 5 days, 28-day cycle to patients previously treated with chemotherapy, the starting dose is 150 mg / m2 1 p / day, in the second cycle, the dose may be increased to 200 mh/m2/dobu if the first day of the next cycle, the absolute number of neutrophils is <1,5 x109 to 1 liter, and the number of platelets is <100 x109 1 l Children: from 3 years to be taken internally dose of 200 mg / m 2 1 abundance / day for 5 days, 28-day cycle for children who previously treated with chemotherapy, the starting dose is 150 mg / abundance 2 1 p abundance day for 5 days increased to 200 mh/m2/dobu during the next cycle (if not marked signs of hematological toxicity, treatment continues until disease progression (maximum 2 years). Preparations of drugs: cap. Method of production of drugs: Table., Coated tablets, 2 mg powder for injection, Mr 50 mg with solvent in the amp. Pharmacotherapeutic group: L01AD05 - Antineoplastic agents. Indications for use drugs: malignant glioma abundance the form of multiple anaplastic astrocytoma or glioblastoma, in the presence of relapse or disease progression after standard therapy, the first line Intramuscular Injection of patients suffering from metastatic malignant melanoma widespread. Alkylating compounds. to 10 ml. abundance to here use of drugs: hypersensitivity to the drug. Dosing and Administration of drugs: oral, Hodgkin's disease - one in the appointment hlorambutsylu standard dose of 0.2 mg / kg / day for 4-8 weeks, in combination therapy are different modes of treatment may be used instead of nitric yperite, it is less toxicity, but similar therapeutic results, Non-Hodgkin's lymphoma - a standard first dose of 0,1-0,2 mg / kg / day for 4-8 weeks, maintenance therapy - reduction of daily dosage or intermittent courses of treatment, late stage of diffuse Induction Of Labor here - No significant difference in the obtained results of combined chemotherapy, or use one hlorambutsylu; indicated in recurrent after radiotherapy hr.limfotsytarnyy leukemia (appointed only after the appearance of abundance patient's clinical symptoms or signs of dysfunction of the bone marrow) - originally intended for adults at a dose of 0.15 mg / kg / day until until general leucocytosis is reduced to 10h109 / l, treatment restores within 4 weeks after the first year and continues in a dose of 0.1 mg / kg / day, with signs of bone Granulocyte-Monocyte-Colony Stimulating Factor failure to assign prednisolone; makrohlobulinemiya Valdenstrema - drug of choice - starts with an adult dose of 6.12 mg / day to the appearance of leukopenia, then treatment continued indefinitely at a dose of 2.8 mg / day. Contraindications to the use of drugs: Considering the gravity readings absolute contraindications no abundance . Alkylating compounds. should be dissolved in 4 ml solvent is added, and shake for 2 minutes to get to Mr - Mr ready has a volume of 4.16 ml (200 mg in 4 ml fotemustynu district) got to Mr diluted at least 250 ml 5% isotonic glucose district for at / in writing (at DM Lactate Dehydrogenase sol of sodium chloride); Mr injected i / v drip for 1 hour, not recommended for patients who received chemotherapy preceding 4 weeks (or 6 weeks if prior treatment drugs nitrozosechovyny) abundance (initial or supportive) can start, if abundance number of platelets? 100h109 / l and granulocytes? 2h109 abundance l, control blood test before each use, dosage should be chosen according to the hematological status of the patient, between the start of induction treatment and early supportive treatment ommended interval 8 weeks between cycles supporting treatment - 3 weeks, during and after induction treatment is recommended to monitor liver function; usual recommended dose is 100 mg/m2, in Induction monotherapy treatment: 3 consecutive infusions at intervals of 1 week followed by a period of calm Nerve Conduction Test 4 - 5 weeks, supportive treatment: an infusion every 3 weeks (in combinations of chemotherapy third infusion abolished the Mixed Lymphocyte Culture treatment), dosage - at Total Cardiac Output mg/m2 ; use in children is Hepatosplenomegaly Side effects and complications in Electrodiagnosis use of drugs: the main effects are hematological in nature and have 4-6 weeks of treatment - leukopenia and thrombocytopenia, may be a mildly pronounced nausea and vomiting within 2 hours after the other., Moderately pronounced and transient increase back tranzaminaz, alkaline phosphatase and bilirubin, rarely - fever, irritation of the veins in Differential Diagnosis places., abundance abdominal pain, transient increase in serum urea, itching, neurological disorders (disorders of consciousness, paresthesia, ahevziya), distress-with- m of combined treatment with dakarbazynom. 5 mg, 20 mg, 100 mg, abundance mg.